Los Mochis is a coastal city in northern Sinaloa, Mexico, located at 25°47′24″N 109°0′0″W25.79°N 109°W. It serves as the municipal seat of the municipality of Ahome. As of the 2005 census, the population was 231,977, or almost 60 percent of the municipality's population.

Los Mochis is the western terminus of the Chihuahua-Pacific Railroad, or ChePe, which passes through the scenic Copper Canyon. This railway was originally conceived by Albert K. Owen and approved by President Porfirio Díaz as a trade route linking the cattle markets in Kansas City with the nearest port on the Pacific Ocean, Topolobampo.

Today the Pacífico Norte irrigation region (Sinaloa-Sonora) in which the "Valle del Fuerte" is the largest district and is the principal agricultural area of Mexico, containing over 70% of all irrigated land and producing sugar cane, cotton, rice, flowers, and many types of vegetables. The valley is one of the largest producers of mangoes in Mexico.

Air transportation is provided by Federal del Valle del Fuerte International Airport. Nearby Topolobampo is the second largest natural deepwater port in the world, known for its commercial fishing and increasingly important role in shipping.